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Not all GLP-1s work the same way for MCAS., Most patients do better on Tirzepatide, the dual incretin with both GLP-1 and GIP receptor agonists. But some mast cells just respond better to semaglutide.
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Effects of tirzepatide, a dual GIP and GLP-1 receptor agonist, on blood pressure, cardiac function, and sympathetic nervous system in stroke-prone spontaneously hypertensive rats
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Mast Cell Activation Syndrome (MCAS) can trigger widespread inflammation, allergies, and unexplained symptoms. GLP-1 medications, such as semaglutide and tirzepatide, may help calm things down
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