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Use of an unapproved triple-hormone receptor agonist bought online led to extreme side effects stemming from intractable diarrhea in a man who obtained the drug online from a direct-to-customer seller. The patient
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Treatment with retatrutide, an agonist to GLP-1, GIP, and glucagon receptors in one molecule, was associated with unprecedented drops in weight from people with or without type 2 diabetes in a pair
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Retatrutide (not yet approved in US but people using anyway) promises even potentially greater weight loss amongst the GLP1 drugs. https://www.nejm.org/doi/full/10.1056/NEJMoa2301972
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