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glp-1 not working anymore Genetics might be the reason why GLP-1 drugs like Ozempic do not work equally on everyone who is trying to lose weight, according to a new study published in Nature., In clinical trials, about 10–15%

Marsoni M251S
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4.4 ★★★★★
Based on 2144 reviews
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Product Reviews
M
Verified Purchase
Morgan prickett
Belleville, US
★★★★★ 5
I Import These to Mexico That's How Good They Are
I have purchased this bone at least 10 times and will keep buying it indefinitely. I have 8 rescue dogs, all extreme chewers , we're talking dogs that destroy absolutely everything. This is the only bone I've found that holds their interest and keeps them coming back for more. I've tried every type of bone on the market. This one wins! My dogs range from 5 lbs to 100 lbs and every single one of them is equally obsessed. I now order 5 at a time because I know they'll all be used. The price point is excellent for what you get, and after constant use across 8 dogs, I haven't noticed any negative effects on their health or teeth. I love these so much that I actually import them to Mexico, that should tell you everything. Every time someone visits and sees how occupied and happy my dogs are, they immediately ask where they can get them too. Benebone, you have a customer for life!!!!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 28, 2026
K
Verified Purchase
Kym Brunner
Houston, US
★★★★★ 5
Aggressive Chewers' Delight!
Super strong and apparently flavorful, my aggressive chewing puppy loves this! Goes at it for ten minutes at a time, several times per day - woohoo!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 3, 2026
S
Verified Purchase
Sarah Margaret Goodman
West Palm Beach, US
★★★★★ 5
Dogs love them and they are very safe for them to chew!
These bones are indispensable if you have a chewing and destructive puppy! (Or any dog, really) ours love them and never get tired of chewing - so far we have had them for a month and no one is tired of them or more importantly has managed to eat any of them. They are a great buy and keep dogs really occupied when they may get bored and feel like causing trouble or chewing something!
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Reviewed in the United States on May 1, 2026
G
Verified Purchase
Greg B.
Charlottesville, US
★★★★★ 5
Durable and a favorite toy
My 7 month old Black Lab loves this bone. She is a chewer and has gone to town on the three ends. They are roughed up a bit but holding up better than expected. Highly recommend for dogs that love to chew.
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Reviewed in the United States on June 6, 2026
L
Verified Purchase
Lea
Alexandria, US
★★★★★ 5
Perfect for aggressive chewers
I have a 2 year old pittie and she chows thru bones in minutes, even those reviewed as "long lasting". This thing is still going strong after 9 months. She was not initially interested, had to spread peanut butter on one end, one time, and now it is her go-to chew toy. Looks a little mangled after all this time but she's not even 75% thru it. Highly recommend, no stomach issues.
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Reviewed in the United States on June 7, 2026

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