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The effect of amycretin, a unimolecular glucagon like peptide 1 and amylin receptor agonist, on body weight and metabolic dysfunction in mice and rats eBioMedicine Balancing weight and muscle loss in GLP1 receptor agonist therapy Nature Reviews Endocrinology GLP 1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal. PDF] Novel dual GLP 1 GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models. Semantic Scholar
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★★★★★ 5
My puppy loves it!
Flavor Name: Y-Gnawt, Size: Medium
I have a lab puppy, who is very energetic and very food motivated. She loves this chew! It’s long lasting and durable, but does make a bit of mess, with bits and pieces of the coating falling off as she chewed.
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Reviewed in the United States on June 11, 2026
★★★★★ 1
Stains carpet!
Flavor Name: Y-Gnawt, Size: Small
I love the original Y-Gnawt. I can't tell you how long it lasts because my dog still has it. I was excited to try this one. My dog went right after this bone. She got the "meaty" stuff off of it in way under 10 minutes. That was disappointing, but the price point is not much higher than the plain ones so I wasn't too mad about that. Here's where the problem comes in, that "meaty" stuff stained my carpet. Between the dog saliva and moving the bone around I had a quite large stain.
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Reviewed in the United States on May 29, 2026
★★★★★ 5
Long lasting
Flavor Name: Y-Gnawt, Size: Large
It's been 15 minutes and my dog is still chewing which never happens. She destroys everything within a few minutes. Everything! The coating is gone but she's still happy. No staining and she's eating it on the carpet.
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Reviewed in the United States on May 16, 2026
★★★★★ 4
Good brand! 💯 for aggressive chewers & Long lasting.
Flavor Name: Antler, Size: Large, Flavor Name: Antler, Size: Large
Honestly Five Stars! 🤩 But Toys could always be improved. My boys Loves Honest chew! 🤍 it's about the Second to third Toy/ Bone 🦴 that is Good & long-term lasting. For My Pit mix & Border collie. Pit mix has a very strong jaw and gotta keep my Border Collie busy! We have Four other bones, they use everyday & keep them busy. Definitely Worth the money! It's easy but watch that first Day! It's messy. Please be careful! of your dog has sensitive stomachs. Always Supervise your fur babies! 🦺 Theses are Toys/ bones, they DON'T last forever. Has they wear down, Please replace them with New ones! 🐶🫶🏾 Thank You Honest chew! We're definitely buy again.
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Reviewed in the United States on April 29, 2026
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Vomit Inducing
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