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Read "Ending the Tobacco Problem: A Blueprint for the Nation" at NAP.edu
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Humans were using tobacco at least 12,000 years ago
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Humans' Earliest Evidence of Tobacco Use Uncovered in Utah
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Did People Smoke Anything Before Tobacco Was Discovered?
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Earliest evidence for human use of tobacco in the Pleistocene Americas
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Humans have been cultivating tobacco since mammoths roamed the Earth. Fast forward several millennia and Europeans colonizing the Americas turned it into such a massive cash crop, they were using tobacco leaves
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History of tobacco
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