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brand name of tirzepatide Semaglutide vs Tirzepatide, same medication class, different receptor targets. Here's what that actually means. Semaglutide targets the GLP-1 receptor, found in the brain, gut, and pancreas. Tirzepatide targets two: GLP-1 and GIP

Marsoni M251S
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Joe
Carnegie, US
★★★★★ 5
Comfortable
Size: 11.5, Color: Black Full Grain
Fit great very comfortable
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 16, 2025
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Verified Purchase
DAVID L.
Los Angeles, US
★★★★★ 5
Nice shoes!
Size: 11, Color: Black Full Grain
I bought them in black and I like them so much I will be buying the brown soon. They fit true to size and are comfortable and stylish. I like the clean simplicity. They're basically a dressy sneaker which is perfect for my job's 'dress code'. Yet they're stylish enough to be worn weekends or a night out. They seemed just a touch stiff out of the box but IMO that's completely normal and fine - after just a couple days of wearing them they are breaking in nicely. No complaints on that. They seem to be of very high quality and I'm very happy with them.
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Reviewed in the United States on February 8, 2026
B
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Bamaphan
Boise, US
★★★★★ 5
Good shoes!!!!!
Size: 10, Color: Tan Full Grain
They are comfortable, they fit, great style. I bought blue, brown and black shoes.
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Reviewed in the United States on August 18, 2025
S
Verified Purchase
Shawn
Dallas, US
★★★★★ 5
Great Product
Size: 13, Color: Black Full Grain
2nd Johnston & Murphy comfortable and stylish.
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Reviewed in the United States on December 26, 2025
M
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Margaret
Charlottesville, US
★★★★★ 5
Great shoes for business casual, corporate travel
Size: 8.5, Color: White Full Grain
Fit true to size
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Reviewed in the United States on December 30, 2025

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