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Tylenol depletes glutathione… your liver's most important protective antioxidant. Every dose chips away at it. So instead of taking lower doses every 4–6 hours, I recommend spacing to 1000mg every 8 hours
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A 48-hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https://bestpractice.bmj.com/topics/en-us/1010
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